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Inhibition of protein kinase B by Palmitate in the insulin signaling of HepG2 cells and the preventiveeffect of Arachidonic acid on insulin resistance

XIA Yanzhi, WAN Xuedong, DUAN Qiuhong, HE Shansu, WANG Ximing

Frontiers of Medicine 2007, Volume 1, Issue 2, Pages 200-206 doi: 10.1007/s11684-007-0038-y

Abstract: Elevated plasma levels of free fatty acids (FFAs) may contribute to insulin resistance (IR) that is characteristic

Keywords： palmitate characteristic study plasma resistance

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Mechanism of insulin resistance in obesity: a role of ATP

Frontiers of Medicine 2021, Volume 15, Issue 3, Pages 372-382 doi: 10.1007/s11684-021-0862-5

Abstract: Obesity increases the risk of type 2 diabetes through the induction of insulin resistance.The mechanism of insulin resistance has been extensively investigated for more than 60 years, but theThe ATP production is elevated in insulin-sensitive cells under obese conditions independent of energyInsulin resistance cuts down the substrate uptake to attenuate mitochondrial overloading.The prevention of ATP overproduction represents a key strategy for insulin sensitization.

Keywords： type 2 diabetes energy expenditure mitochondria hyperinsulinemia hyperglucagonemia AMPK

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Mechanisms of insulin resistance in obesity

Jianping Ye

Frontiers of Medicine 2013, Volume 7, Issue 1, Pages 14-24 doi: 10.1007/s11684-013-0262-6

Abstract:

Obesity increases the risk for type 2 diabetes through induction of insulin resistance.Treatment of type 2 diabetes has been limited by little translational knowledge of insulin resistancealthough there have been several well-documented hypotheses for insulin resistance.resistance, in which insulin resistance is a result of energy surplus in cells., which may apply to insulin resistance in aging and lipodystrophy.

Keywords： type 2 diabetes energy expenditure inflammation lipotoxicity mitochondria hyperinsulinemia adenosine monophosphate-activated protein kinase (AMPK)

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Insulin resistance and the metabolism of branched-chain amino acids

Jingyi Lu, Guoxiang Xie, Weiping Jia, Wei Jia

Frontiers of Medicine 2013, Volume 7, Issue 1, Pages 53-59 doi: 10.1007/s11684-013-0255-5

Abstract:

Insulin resistance (IR) is a key pathological feature of metabolic syndrome and subsequently causesThe BCAAs are particularly responsive to the inhibitory insulin action on amino acid release by skeletalmuscle and their metabolism is profoundly altered in insulin resistant conditions and/or insulin deficiencyAlthough increased circulating BCAA concentration in insulin resistant conditions has been noted for

Keywords： branched-chain amino acids leucine isoleucine valine insulin resistance

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Role of exercise training on insulin resistance and TNF-α in high-fat diet rats

Hui SUN MD, Xiuling DENG MM, Fangxi XIAO MD, Lulu CHEN MD, Huiqing LI MD,

Frontiers of Medicine 2009, Volume 3, Issue 4, Pages 403-407 doi: 10.1007/s11684-009-0071-0

Abstract: This study investigated the effect of exercise training on insulin resistance and serum and adipose TNF-α in high-fat diet-induced insulin-resistant rats.Changes of body weight, lipid profile, and fasting plasma glucose and insulin were measured.The insulin sensitivity index (ISI) was calculated.In conclusion, exercise training ameliorates insulin resistance.

Keywords： exercise training insulin resistance tumor necrosis factor-α

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Overcoming oral insulin delivery barriers: application of cell penetrating peptide and silica-based nanoporous

Huining HE, Junxiao YE, Jianyong SHENG, Jianxin WANG, Yongzhuo HUANG, Guanyi CHEN, Jingkang WANG, Victor C YANG

Frontiers of Chemical Science and Engineering 2013, Volume 7, Issue 1, Pages 9-19 doi: 10.1007/s11705-013-1306-9

Abstract: Oral insulin delivery has received the most attention in insulin formulations due to its high patientHowever, oral insulin delivery has two major limitations: the enzymatic barrier that leads to rapid insulindegradation, and the mucosal barrier that limits insulin’s bioavailability.In vitro studies demonstrated that the CPP-insulin conjugates could facilitate cellular uptake of insulinwhile keeping insulin’s biologic functions intact.

Keywords： insulin cell penetrating peptide mucoadhesive composites oral delivery

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Lingguizhugan Decoction, a Chinese herbal formula, improves insulin resistance in overweight/obese subjects

Frontiers of Medicine 2022, Volume 16, Issue 5, Pages 745-759 doi: 10.1007/s11684-021-0880-3

Abstract: Lingguizhugan Decoction (LGZG) has been investigated in basic studies, with satisfactory effects on insulinThe primary efficacy variable was homeostasis model assessment of insulin resistance (HOMA-IR).Low-dose LGZG effectively improved insulin resistance in overweight/obese subjects with NAFLD.

Keywords： insulin resistance non-alcoholic fatty liver disease Chinese herbal medicine randomized controlled

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Effects of resistin on insulin signaling in endothelial cells

Zhizhen LI, Fangping LI, Jianhong YE, Li YAN, Zuzhi FU

Frontiers of Medicine 2009, Volume 3, Issue 2, Pages 136-140 doi: 10.1007/s11684-009-0029-2

Abstract: The objective of this study was to investigate the effects of resistin on insulin signaling in humanendothelial nitric oxide synthase (eNOS) phosphorylation levels of endothelial cells under basal or insulincould significantly inhibit Akt and eNOS phosphorylation and NO production in endothelial cells under insulinThese findings suggested that resistin exerted an inhibitory effect on NO production by inhibiting insulin

Keywords： resistin endothelium nitric oxide endothelial nitric oxide synthase Akt-binding protein mouse

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A Smart Pill for Insulin?

Elizabeth K. Wilson

Engineering 2019, Volume 5, Issue 4, Pages 603-604 doi: 10.1016/j.eng.2019.07.008

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Molecular mechanisms of fatty liver in obesity

Lixia Gan,Wei Xiang,Bin Xie,Liqing Yu

Frontiers of Medicine 2015, Volume 9, Issue 3, Pages 275-287 doi: 10.1007/s11684-015-0410-2

Abstract: Insulin resistance associated with central obesity is the major cause of hepatic steatosis, which is

Keywords： nonalcoholic fatty liver disease insulin resistance obesity

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Zinc homeostasis in the metabolic syndrome and diabetes

Xiao Miao, Weixia Sun, Yaowen Fu, Lining Miao, Lu Cai

Frontiers of Medicine 2013, Volume 7, Issue 1, Pages 31-52 doi: 10.1007/s11684-013-0251-9

Abstract: roles of Zn: (1) a constructive component of many important enzymes or proteins, (2) a requirement for insulinstorage and secretion, (3) a direct or indirect antioxidant action, and (4) an insulin-like action.

Keywords： zinc zinc transporters metallothionein diabetes diabetic complications insulin resistance antioxidant

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Xiao Ke Qing improves glycometabolism and ameliorates insulin resistance by regulating the PI3K/Akt pathway

Xiaoqing Li, Xinxin Li, Genbei Wang, Yan Xu, Yuanyuan Wang, Ruijia Hao, Xiaohui Ma

Frontiers of Medicine 2018, Volume 12, Issue 6, Pages 688-696 doi: 10.1007/s11684-018-0662-8

Abstract: Moreover, XKQ can ameliorate insulin resistance and upregulate the expression of IRS-1, PI3K (p85), p-AktXKQ is an effective drug for T2DM by ameliorating insulin resistance and regulating the PI3K/Akt signaling

Keywords： XKQ type 2 diabetes mellitus KKAy mice PI3K/Akt pathway diabetic liver disease

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Beneficial metabolic activities of inflammatory cytokine interleukin 15 in obesity and type 2 diabetes

Jianping Ye

Frontiers of Medicine 2015, Volume 9, Issue 2, Pages 139-145 doi: 10.1007/s11684-015-0377-z

Abstract:

In obesity, chronic inflammation is believed to induce insulin resistance and impairs adipose tissueof literature, it has been challenged by growing evidence that pro-inflammatory cytokines may favor insulinIL-15 suppresses lipogenesis, stimulates brown fat function, improves insulin sensitivity through weight

Keywords： inflammation obesity cytokine energy expenditure insulin resistance

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Prokaryotic expression and bioactivity analysis of growth hormone and insulin-like growth factor-I from

Xu Yongjiang,Zang Kun,Liu Xuezhou,Shi Bao and Chen Shengyi

Strategic Study of CAE 2015, Volume 17, Issue 1, Pages 67-73

Abstract:

The mature peptide domain of insulin-like growth factor-I from Platichthys stellatus were amplified

Keywords： Platichthys stellatus； insulin-like growth factor-I； prokaryotic expression； bioactivity

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Metformin and metabolic diseases: a focus on hepatic aspects

Juan Zheng,Shih-Lung Woo,Xiang Hu,Rachel Botchlett,Lulu Chen,Yuqing Huo,Chaodong Wu

Frontiers of Medicine 2015, Volume 9, Issue 2, Pages 173-186 doi: 10.1007/s11684-015-0384-0

Abstract: While generating beneficial effects on hyperglycemia, metformin also improves insulin resistance and

Keywords： metformin diabetes hepatic steatosis inflammatory response insulin resistance

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Title Author Date Type Operation

Inhibition of protein kinase B by Palmitate in the insulin signaling of HepG2 cells and the preventiveeffect of Arachidonic acid on insulin resistance

XIA Yanzhi, WAN Xuedong, DUAN Qiuhong, HE Shansu, WANG Ximing

Journal Article

Mechanism of insulin resistance in obesity: a role of ATP

Journal Article

Mechanisms of insulin resistance in obesity

Jianping Ye

Journal Article

Insulin resistance and the metabolism of branched-chain amino acids

Jingyi Lu, Guoxiang Xie, Weiping Jia, Wei Jia

Journal Article

Role of exercise training on insulin resistance and TNF-α in high-fat diet rats

Hui SUN MD, Xiuling DENG MM, Fangxi XIAO MD, Lulu CHEN MD, Huiqing LI MD,